Lipid Nanocarriers in Drug Delivery System

Question: Discuss about theLipid Nanocarriers in Drug Delivery System. Answer: Introduction The nanocarriers are widely used as drug delivery system that can be used as the chemotherapeutic agents in order to improve the pharmacological properties of the drugs. The size of the nanocarriers can vary from a range of 1-1000nm. Due to the small size of the nanocarriers, it is possible to deliver the drugs in many inaccessible positions within the human body. This is not possible for the traditional form of drugs due to the large size. The nanocarriers are mainly of the lipid-based molecules and carbon nanotubes. The lipid based molecules are mainly composed of the micelles and liposome. The materials that are composed of these nanocarriers are amphphilic in nature, which has both hydrophilic and hydrophobic nature. This property of the medicines helps them to reach in every part of the body. According to Mura, Nicolas Couvreur (2013), the colloidal system of the drug delivery system helps in the miscellar solution. Due to the Amphiphilic nature of the drug it has the ability to change the molecular interaction property of the surrounding molecules of the body. The micelles thus formed with the help of the Amphiphilic polymers of lipid molecules can be of great use in the drug delivery system. It is possible for the drug to get blocked within the micelles structure thus formed. In this research proposal, the impact of the lipid based nanocarriers, which is amphphilic in nature are discussed. The aim of the researcher is to discover new techniques to improve the use of nanocarriers as pharmaceutical drugs. The researcher will also highlight upon the importance of the previously done research of the contextual topic. Literature Review In the recent times, with the advancement of nanotechnology, the field of medical biology has able to improve the both the department of diagnostic and treatment. According to Puri et al., (2009), the formation of the active bioactive molecules that is inert and non-toxic in nature helps in the improvement of the therapeutic nature and also reduce the side-effects. The liposome, which is composed of phospholipids and is amphipathic in nature, forms a bilayred structure. Depending upon the number of layers in the bilayer structure, the liposome can be classified as small unilamellar structure (SUVs), large unilamellar (LUVs) and multilammer (MLV). The size of the particles may vary from 0.025-10 micrometer. The vesicles that are formed by the self assembly of the amiphilovilc lipid like particles can work as effective drug delivery system. The modifications in the drug design procedure will help to the capacity of the drug to carry out the medical activities and target the receptor cells inn more accurately by minimizing the side-effects. Gomes-da-Silva et al., (2012), believes due to higher cost effective benefits of the nanomediciens, the use of this type of treatment will increase in the recent future. Moreover, the drugs are bio-degrabadable and less toxic in nature. The glycolipids bio-surfactants can act as potential carriers for the drugs. According to Feng Mumper (2013), the main purpose for the introduction of the nanostructed lipid carries is to overcome the difficulties that were associated with solid lipid nanoparticles. The expulsion process of the drugs can be prevented with the help of the nanostructured lipid particle carries. Reference Feng, L., Mumper, R. J. (2013). A critical review of lipid-based nanoparticles for taxane delivery.Cancer letters,334(2), 157-175. Gomes-da-Silva, L. C., Fonseca, N. A., Moura, V., Pedroso de Lima, M. C., Simo?es, S., Moreira, J. N. (2012). Lipid-based nanoparticles for siRNA delivery in cancer therapy: paradigms and challenges.Accounts of Chemical Research,45(7), 1163-1171. Mura, S., Nicolas, J., Couvreur, P. (2013). Stimuli-responsive nanocarriers for drug delivery.Nature materials,12(11), 991-1003. Puri, A., Loomis, K., Smith, B., Lee, J. H., Yavlovich, A., Heldman, E., Blumenthal, R. (2009). Lipid-based nanoparticles as pharmaceutical drug carriers: from concepts to clinic.Critical Reviews in Therapeutic Drug Carrier Systems,26(6).